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Although APX activity has been reported in a number of non-plants, it appears that a fundamental difference between mammals and plants is an additional high capacity H 2 O 2 ascorbate-based scavenging system [2], [22] in the latter to complement catalase as well as the more widely conserved peroxiredoxin and glutathione peroxidase-like systems [23], [24]

The majority of these involved targeting the IGF-1R, either with monoclonal antibodies (mAbs) causing internalization of the receptor, or by blocking the receptors tyrosine kinase domain activation using receptor tyrosine kinase inhibitors (RTKIs)

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